Pharmacological and Parenteral Therapies

The nurse must be able to safely administer medications and other therapeutics as well as differentiate between intended effects and side effects. The Pharmacological and Parenteral Therapies subcategory of the NCLEX-RN exam covers topics related to medication administration, injections, and infusions. This section covers blood product administration, dosage calculating, venous access, and other issues pertinent to medication and parenteral therapies.

The patient is admitted to the hospital with systemic syphilis infection. The patient is ordered to receive a 14-day course of penicillin G 20 million units/day intravenously. Prior to administering the medication, the nurse checks the patient’s allergies and learns the patient experienced anaphylaxis after receiving ampicillin. Which action does the nurse take?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 7
  • Topics: Communication & Documentation Disease Prevention Health Care Quality Health Promotion Immunity Infection Inflammation Medication and Blood Products Nursing Interventions Routes of Administration

A patient’s central line appears occluded. Which method does the nurse use to determine if the catheter occlusion is internal?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 9
  • Topics: Routes of Administration Cardiovascular

A nurse is caring for a patient who is recovering from total hip replacement surgery. The patient has required increasing doses of IV morphine for pain control. The patient is again reporting 10/10 pain despite receiving 10 mg of morphine from the nurse, which is the top of the range ordered by the physician. The nurse monitors which of the following most closely?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 4
  • Topics: Neurology Respiratory Assessment Communication & Documentation Health Care Quality Health Promotion Medication and Blood Products Routes of Administration

The parent reports giving the child 1 teaspoon of ibuprofen suspension. The nurse charts which volume in milliliters?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 2
  • Topics: Weight-Based Dosing Medication and Blood Products Communication & Documentation Routes of Administration

The nurse reviews which components of total parenteral nutrition (TPN) prior to administering them? Select all that apply.

  • Question Type:   Multiple Choice - Select All
  • Difficulty: 6
  • Topics: Routes of Administration Assessment Medication and Blood Products

The nurse is teaching the child with asthma how to use a metered-dose inhaler. Which instructions does the nurse include? Select all that apply.

  • Question Type:   Multiple Choice - Select All
  • Difficulty: 5
  • Topics: Medication and Blood Products Pediatrics Respiratory Health Promotion Inflammation Nursing Interventions Routes of Administration

A patient with gram-negative sepsis is in the ICU after cardiac arrest. He requires a vasopressor for severe hypotension. Which patient characteristic would prompt the nurse to hold the infusion and contact the provider?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 7
  • Topics: Medication and Blood Products Cardiovascular Communication & Documentation Delegation, Prioritization and Leadership Health Care Quality Routes of Administration

Which is the mechanism of action of naproxen sodium?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 4
  • Topics: Neurology Medication and Blood Products

Local anesthetics have which mechanism of action?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 2
  • Topics: Neurology Medication and Blood Products Routes of Administration

The 42 weeks gestation pregnant woman is about to undergo labor induction. The nurse anticipates administering which medication?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 3
  • Topics: Labor and Delivery Medication and Blood Products Prenatal Care Routes of Administration

The physician writes an order for diphenhydramine 250 mg PRN for sleep. Which part of the order does the nurse question?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 6
  • Topics: Neurology Communication & Documentation Delegation, Prioritization and Leadership Health Care Quality Intracranial Regulation Medication and Blood Products Routes of Administration

The patient with congestive heart failure in the cardiac intensive care unit (CICU) is ordered to receive IV furosemide once per day. The lab just called and reported the patient’s serum potassium is 2.9 mEq/L. The next dose of furosemide is due now. Which is the appropriate nursing action?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 6
  • Topics: Cardiovascular Medication and Blood Products Communication & Documentation Elimination Fluid and Electrolytes Routes of Administration

The nurse is caring for a patient with pneumonia and fulminant pulmonary arterial hypertension. The patient is intubated and mechanically ventilated receiving inhaled nitric oxide (iNO). Additionally, the patient has a central line with multiple continuous infusions, including norepinephrine, vecuronium, morphine, and propofol. During the shift, the nurse begins to have difficulty breathing, a dry throat, syncope, and chest pain. Which action does the nurse take first?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 10
  • Topics: Cardiovascular Respiratory Routes of Administration

The patient receiving inhaled nitric oxide (iNO) is at risk for which adverse event?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 6
  • Topics: Cardiovascular Hematology/Oncology Respiratory Routes of Administration

Which test does the nurse expect will be used to determine the effectiveness of the fosphenytoin dose?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 4
  • Topics: Medication and Blood Products Neurology

The nurse learns the patient who takes fosphenytoin was prescribed apixaban two months ago. The nurse assesses the patient for which complication caused by taking these two medications together?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 8
  • Topics: Cardiovascular Hematology/Oncology Neurology

The unresponsive patient is brought to the emergency department via ambulance. During an abbreviated neurologic exam, the nurse notes the following pupils, estimated to be 1 mm and fixed: The nurse prepares to administer which medication?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 6
  • Topics: HEENT Lifestyle Choices and High Risk Behavior Neurology

The patient has been taking apixaban for 4 weeks. Which monitoring test does the nurse review to evaluate the efficacy of the medication?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 5
  • Topics: Cardiovascular Hematology/Oncology Neurology

The 2.1 kg neonate with hypoxic ischemic encephalopathy is in status epilepticus that is refractory to 2 loading doses of phenobarbital. The provider has ordered 20 mg/kg to be administered intravenously STAT. The pharmacy dispenses the medication in a concentration of 50 mg/mL. How many milliliters does the nurse administer? Input your answer to the hundredth decimal.

  • Question Type:   Fill in the Blank
  • Difficulty: 5
  • Topics: Neurology Routes of Administration Weight-Based Dosing

The 4.5 kg neonate with hypoxic ischemic encephalopathy is in status epilepticus that is refractory to 2 loading doses of phenobarbital. The provider has ordered 20 mg/kg to be administered intravenously over 15 minutes STAT. The pharmacy dispenses the medication in a concentration of 50 mg/mL. What rate will the nurse program the pump to administer the medication? Round your answer to the tenth decimal place.

  • Question Type:   Fill in the Blank
  • Difficulty: 7
  • Topics: Neurology Routes of Administration Weight-Based Dosing

The 64-year-old male patient with chronic obstructive pulmonary disease related to a 42-pack-year history of smoking is receiving ipratropium bromide. Which symptom indicates the patient is experiencing an adverse effect of this medication?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 6
  • Topics: Cardiovascular Respiratory

Which statement by the patient with asthma indicates a need for further teaching?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 7
  • Topics: Cardiovascular Communication & Documentation Respiratory

The nurse plans care for the patient who is receiving theophylline for the treatment of refractory asthma. Which nursing intervention does the nurse include to assess for complications of the drug?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 7
  • Topics: Cardiovascular Respiratory

The condition of the patient with a pulmonary hypertensive crisis due to pneumonia has improved. Which order does the nurse question?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 7
  • Topics: Cardiovascular Communication & Documentation Respiratory Routes of Administration

The patient who takes milk of magnesia every day is at risk for which electrolyte imbalance?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 6
  • Topics: Acid-Base Disease Prevention Health Screening Medication and Blood Products Elimination Fluid and Electrolytes

The nurse is reviewing a patient’s medications during discharge. Which further education can the nurse provide regarding spironolactone when the patient asks, “I thought that I took a furosemide pill for my water?”

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 8
  • Topics: Acid-Base Cardiovascular Medication and Blood Products Communication & Documentation Elimination Fluid and Electrolytes Patient Education

The nurse questions the order for an infusion of 0.45% NaCl in the patient with which condition?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 5
  • Topics: Communication & Documentation Neurology Fluid and Electrolytes Intracranial Regulation

Which patient characteristic prompts the nurse to hold the infusion of Lactated Ringer’s and contact the provider?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 8
  • Topics: Acid-Base Communication & Documentation Assessment Cardiovascular Elimination Fluid and Electrolytes Medication and Blood Products Nursing Interventions

The 16-year-old patient passed out from the heat while playing football and now requires an infusion of Lactated Ringer’s solution for moderate dehydration. The patient’s heart rate is 118 bpm, blood pressure is 100/72 mmHg, and temperature is 37.5°C. Which gauge of intravenous catheter does the nurse select for insertion into this patient?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 6
  • Topics: Growth & Development Routes of Administration

The patient calls the nurse to the room to report pain at the site of an IV. The nurse notes warmth, redness, and purulent drainage. Which action does the nurse take first?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 6
  • Topics: Communication & Documentation Disease Prevention Routes of Administration Infection Inflammation Tissue Integrity

The patient receiving a rapid infusion of Lactated Ringer’s solution for dehydration calls out to report difficulty breathing and a racing heart. Upon assessment, the nurse notes decreased level of consciousness and severe hypotension. Which assessment does the nurse make first?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 6
  • Topics: Cardiovascular Routes of Administration

The patient receiving a continuous infusion of total parenteral nutrition (TPN) through a peripherally inserted central catheter (PICC) line reports sudden onset dizziness, dyspnea, and tachycardia. Upon assessment, the nurse notes the patient is difficult to arouse. The IV tubing is noted to be cracked and have air in it. Which action does the nurse take first?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 7
  • Topics: Cardiovascular Routes of Administration

The nurse suspects the patient has experienced an air embolism from the peripherally inserted central catheter (PICC). Place the steps the nurse takes to intervene in the correct order.

  • Question Type:   Put in Order
  • Difficulty: 9
  • Topics: Cardiovascular Routes of Administration

The nurse is instructing the patient on how to move in bed after an open abdominal surgery. Which statement by the nurse is appropriate?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 6
  • Topics: Communication & Documentation Disease Prevention Gastrointestinal

Which term does the nurse use to describe the patient who takes oxycodone daily for pain associated with deteriorating knee cartilage and requests a higher dosage for breakthrough pain?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 4
  • Topics: Communication & Documentation Musculoskeletal Medication and Blood Products

The patient with poorly controlled type II diabetes mellitus reports burning pain in the feet and legs that keep him up at night. The nurse passes this report along the provider and advocates for which medication for the patient?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 6
  • Topics: Communication & Documentation Endocrine Neurology

Fentanyl must be used with caution in which patient?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 10
  • Topics: HEENT Neurology Intracranial Regulation Medication and Blood Products Routes of Administration

The elderly patient receiving a continuous morphine infusion for the treatment of cancer pain is at risk for opioid-induced respiratory depression. The nurse selects which monitoring device to most quickly detect a change in the patient’s respiratory drive?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 8
  • Topics: Cardiovascular Neurology Respiratory

The patient receiving a continuous hydromorphone infusion for severe cancer pain is found to be unconscious with a respiratory rate of 7 breaths per minute. Which action does the nurse take first?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 8
  • Topics: Cardiovascular Delegation, Prioritization and Leadership Neurology Respiratory

Which patient is at greatest risk for respiratory depression due to the inability to adequately excrete fentanyl?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 7
  • Topics: Respiratory

The nurse is evaluating discharge teaching for the patient receiving hydrocodone/acetaminophen for the treatment of acute pain due to femur fracture. Which statement by the patient indicates teaching was effective?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 8
  • Topics: Communication & Documentation Gastrointestinal Respiratory

What is the main rationale for prescribing hydrocodone with acetaminophen?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 3
  • Topics: Gastrointestinal Neurology Respiratory

The nurse has received an update from the unlicensed assistive personnel about four patients. Which patient does the nurse assess first?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 7
  • Topics: Delegation, Prioritization and Leadership Gastrointestinal Hematology/Oncology

The patient with scoliosis experiences severe pain due to muscle spasms related to the misalignment of the spine. Which medication does the nurse anticipate to be ordered for this condition?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 4
  • Topics: Musculoskeletal Medication and Blood Products Neurology

The patient with chronic renal failure has been prescribed erythropoietin. The nurse informs the patient the drug has which intended effect?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 2
  • Topics: Hematology/Oncology Cardiovascular Elimination Immunity Patient Education

Which statements are true regarding intravenous immunoglobulin? Select all that apply.

  • Question Type:   Multiple Choice - Select All
  • Difficulty: 3
  • Topics: Medication and Blood Products Hematology/Oncology Immunity Inflammation

Which statements are true regarding peripherally inserted central catheters (PICCs)? Select all that apply.

  • Question Type:   Multiple Choice - Select All
  • Difficulty: 6
  • Topics: Routes of Administration Health Promotion Medication and Blood Products Nursing Interventions

The patient is being discharged from hospital on total parenteral nutrition (TPN). Which information does the nurse include in discharge teaching?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 6
  • Topics: Routes of Administration Communication & Documentation Disease Prevention Health Promotion Immunity Infection Medication and Blood Products Patient Education

Which medication may be prescribed for the treatment of anorexia and cachexia related to cancer?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 1
  • Topics: Gastrointestinal Medication and Blood Products Neurology Health Promotion Hematology/Oncology

The nurse is examining the waveform produced by the patient's central venous pressure (CVP) catheter. Atrial contraction occurs at which point on the waveform?

  • Question Type:   Multiple Choice - Select One
  • Difficulty: 8
  • Topics: Cardiovascular Assessment

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