Guillain-Barré Syndrome is characterized by a progressive paralysis that typically starts from the lower extremities and moves upwards, eventually paralyzing the diaphragm and causing artificial ventilation to become necessary. Typically, symptoms of Guillain-Barré Syndrome fully resolve on their own. Irreversible motor deficits occur with amyotrophic lateral sclerosis (ALS), not with Guillain-Barré Syndrome. Nerve pain that occurs in flares is typical of multiple sclerosis, not with Guillain-Barré Syndrome. Guillain-Barré Syndrome typically follows an ascending pattern. While there have been cases of Guillain-Barré Syndrome that follow a descending pattern, this is highly atypical and is not what would be taught to the patient’s family.