Naltrexone is used to treat opioid overdose. The rapid stripping of the opioid receptors can cause seizures and cardiopulmonary arrest. Based on the information in the question, the patient does not require contact and droplet precautions. Medications such as disulfiram that are used in the treatment of alcohol abuse can cause a reaction with alcohol-based hand sanitizers; this is not true of naloxone. The patient who has been prescribed naloxone is likely in respiratory distress. Taking a set of vitals wastes valuable time and doesn’t change management. The patient is not likely to be conscious, so explaining the purpose of the medication would be futile.