Highly acidic and highly basic medications are harmful to veins and place the patient at significant risk for extravasation. In order to minimize the risk for extravasation, the nurse should first administer medications starting with the highest risk for extravasation, then the next highest risk, and so on. Therefore, the drug with the pH farthest from 7 must be administered first. The drug with the pH of 10 is the farthest from neutral, so it is administered first. The second drug to be administered is the drug with a pH of 5. The third drug to be administered is the one with a pH of 8. The last drug to be administered is the neutral one: the one with pH = 7.