Trisomy 18 is a lethal genetic mutation; most patients do not survive past the first few days of life. Therefore, a palliative care plan satisfies the principle of non-maleficence because it would ensure the patient is not subjected to painful procedures that would not ultimately improve the quality or duration of the patient’s life. Beneficence is an ethical principle that refers to acting in a way that is a benefit to the patient. Autonomy is principle that promotes patient self-determination by giving due consideration to the patient’s competent decisions concerning healthcare. Justice is an ethical provision that refers to fair allocation of resources among all patients in the medical institutions.