At delivery, the neonate is noted to have diffuse purple lesions over the entire body and is taken to the neonatal intensive care unit for further assessment and management. The nurse notes the toes have turned black; pedal pulses are palpable. The nurse anticipates testing will reveal a deficiency in which substance?

Protein C. Neonates born with Protein C Deficiency develop neonatal purpura fulminans, which is characterized by diffuse purpuric rash and disseminated intravascular coagulopathy (DIC), which may present as clots in the peripheral microvascular resulting in necrotic digits. Factor X deficiency presents with excessive bleeding times. Von Willebrand disease, a deficiency of von Willebrand's factor, leads to excessive bleeding as well. Endogenous heparin deficiency is less specific but would lead to clotting problems, although not as impressive as Protein C deficiency.

At delivery, the neonate is noted to have diffuse purple lesions ...

Category: Reduction of Risk Potential
Difficulty: 10

Topics: Genetics Hematology/Oncology Neonatal Care Pediatrics Tissue Integrity

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