The patient with a history of depression and generalized anxiety disorder presents to the clinic seeking information on advance directives. Which action(s) by the nurse are appropriate? Select all that apply.

Which neurotransmitter system is affected by the drug of choice for major depressive disorder? 

The nurse is caring for an elderly patient prone to delirium. In the middle of the night, the patient wakes up agitated and upset and insists that she is late for an appointment. Which response by the nurse is appropriate?