Lissencephaly often presents with severe seizures and developmental delays in infancy and is reflected by a smooth brain that lacks gyri and sulci. Anencephaly is the failure of the brain to develop in utero and is generally diagnosed prenatally or immediately upon delivery due to significant microcephaly. Schizencephaly leads to abnormal clefts in the cerebrum. Holoprosencephaly is the failure of the brain to divide into hemispheres.