Dehydroepiandrosterone (DHEA) is commonly used as a natural remedy for erectile dysfunction. It should not be taken by individuals with breast cancer because it converts to estrogen in the body, which can worsen the condition. It is metabolized in the liver, so individuals with hepatitis C, which can cause liver dysfunction, should be cautioned against its use. Additionally, it can affect the neurotransmitters involved with major depressive disorder and bipolar disorder. DHEA can cause altered glucose metabolism, leading to both hyperglycemia and hypoglycemia.