The nurse is most suspicious of glucose-6-phosphate dehydrogenase (G6PD) deficiency in which patient who presents with jaundice and fatigue after receiving an antimalarial drug?  

The nurse is assigned a patient with Hodgkin’s lymphoma undergoing initial treatment. On the patient’s second day, he develops an acute painful swelling and erythema of the right gastrocnemius. The following morning, the patient develops an acute shortness of breath and pleuritic chest pain. Within minutes, the patient loses consciousness and dies. Which of the following interventions would most likely have prevented this patient’s death?

The patient with cholestasis complains of significant pruritus. The nurse bases the explanation on which understanding of the pathophysiology behind the patient's pruritus?