Local anesthetics have which mechanism of action?

The nurse is evaluating the patient’s response to therapy with 1-deamino-8-ᴅ-arginine vasopressin (DDAVP) for treatment of mild bleeding caused by hemophilia A. Which assessment indicates the patient is experiencing an adverse effect to therapy?  

The 5-year-old child is brought to the emergency department (ED) after a fall at school that has resulted in a broken wrist. The nurse notes the child is thin, with curved femurs and kyphosis. Metaphyseal fraying and cupping is noted on x-ray of the wrist. There is evidence of old fractures that healed poorly, as if they hadn’t been set properly. Upon review of the patient’s medical history, it does not appear that the patient has received ongoing well-child care. After laboratory evaluation, the child is diagnosed with rickets. The nurse prepares information on which medication for the family?