Which degenerative neurologic disorder is caused by neurofibrillary tangles and amyloid plaques?

The patient who recently lost her young child to acute lymphoblastic leukemia (ALL) tells the nurse that she is having trouble handling the grief and feels like she is to blame for her child’s death. Which response by the nurse is most appropriate? 

The patient with major depressive disorder who has been off medication for a couple of years has been prescribed fluoxetine (Zoloft) again. The patient states, "I'm concerned about starting this medication again. I'm a taxi driver and it always used to make me so sleepy." Which instruction from the nurse is appropriate?