The patient undergoing fluid resuscitation for diabetic ketoacidosis (DKA) is at risk for cerebral edema, which presents as decreased level of consciousness despite improving lab studies. Mannitol is an osmotic diuretic administered to decrease cerebral edema. Long-acting insulin is not administered until the patient’s DKA has resolved. Hypotonic saline would worsen cerebral edema; in fact, hypertonic saline may be used in place of mannitol. A 10% dextrose solution is administered when the patient’s blood glucose level has decreased sufficiently but is not used to treat cerebral edema.